If you believe the anti-piracy lobbies, Audible Magic’s CopySense system is the absolute best system you can buy, protecting Universities, and more importantly, their students, from copyright violation accusations. However, the question has to be asked, “Does it really work?”
CopySense Sleek Predator, or White Elephant? | TorrentFreak

Maybe it can with direct HTTP downloads, but I don't think it can block BT or eMule, for example. BitTorrent uses a random piece algorithm and also its own protocol - check data being transfered from and to other peers with a packet sniffer, and it looks nothing like an MP3/etc. eMule also zlib-compresses traffic and has obfuscation...